Always on top
Floats above your EHR, your PDF viewer, anything. Borderless, draggable from the header, resizable from the corner, and semi-transparent so you can still read what is underneath.
Free Academic Edition — study, teaching & research
Check an interaction without leaving the chart.
Rxference drug interactions without taking your phone out pulling up a search engine asking an LLM looking unprofessional in front of a patient taking your phone out, pulling up a search engine, asking an LLM, or looking unprofessional in front of a patient.
Live demo
Demo data only — a small slice of what the installed app carries.
Use the online version Search all 8,000+ drugs in your browser. No account, no download.
Click to try these examples:
This is the real thing, running in your browser on the app's own curated
tier — 39 entries and
122 severity-graded
interactions, every one of them citing the FDA label section that
supports it. The installed app adds the full database:
8,343 more drugs. Collapse it with ─, change the theme and
transparency under ⚙.
Reference aid for licensed clinicians — not medical advice, and not
exhaustive. Read the full terms.
Rxference is a floating, always-on-top drug and interaction reference. Search a drug, read the card, copy the name in one click — then collapse it back to a small pill that's out of your way.
Already downloaded? Register for your academic license here
The Academic Edition is licensed for study, teaching and research. Using it while caring for a patient, or across a practice, needs the Professional Edition — join the waitlist. Both editions carry the same data and the same features; nothing is held back. Read the license or the intended-use statement.
Three keystrokes, no window switching
Rxference is a transparent overlay so that you never lose your place. Everything below happens without touching the application underneath.
Search
Type a generic name, a brand, or the name of a drug you want to check against — searching a drug also finds everything recorded as interacting with it.
Read
What it is prescribed for, and the interactions that matter, graded major / moderate / minor. See more info opens dosing, cautions and the complete list.
Collapse
One click shrinks it to a 54px ℞ pill — placed exactly where the button was, so reopening is the same click in the same spot. No mouse travel.
Features
Built to be in the way as little as possible
Works offline, always
The whole database is local. No account, no telemetry, and nothing you search for leaves the machine. The one request it makes is a daily check for a new version — what that involves.
One key from anywhere
A system-wide shortcut — Ctrl + Shift + Space by default — brings the window forward and puts the cursor in the search box without you leaving the chart. Change it if it clashes with something you already use.
Copy the name in one click
One click copies the drug name to the clipboard, ready to paste into a prescription field. Ctrl+C takes any text you have selected from the card.
Two themes, four opacities
Dark and light, and a transparency control, because an overlay that works in a bright surgery does not work in a dim reading room.
Versioned data
Every database records which FDA export it came from and when it was downloaded. About tells you, and the app can check whether a newer export exists.
Where every line comes from
Four sources, each labelled in the app wherever its data appears. You should never have to guess whether what you are reading was reviewed by a person or lifted from a label.
Curated tier
40 drugs · 128 sourced interactionsSeverity gradings for the drugs actually prescribed chairside. Each one names the label section that supports it and links to the current label; the prose is the label’s own. Ranked first.
Graded against FDA labellingopenFDA labels
8,343 drugsThe FDA's own label corpus, deduplicated by ingredient code and folded through RxNorm so salt and hydrate forms share one entry. Label prose, presented as label prose.
Public domainFDA CYP & transporter tables
207 drugs · 19 pathwaysPharmacokinetic interactions inferred from the FDA's substrate, inhibitor and inducer tables. Kept in a section of their own and every one labelled a prediction.
Public domainLabel-cited interactions
9,285 edges · 785 drugsAcross the 1,000 most-prescribed ingredients. An interaction is listed only where one drug's own FDA label names the other, and every one quotes the sentence and links to the exact label document.
Public domainWhat it won't do
A reference tool earns its place by being trusted, and nothing costs trust faster than confident-sounding output that turns out to be a guess. So:
- It won't invent a severity. Where a source records a pair without grading it, the app shows it ungraded rather than picking a colour.
- It won't pass a prediction off as a finding. Mechanism-derived interactions live in their own section, each naming its pathway, and never enter the curated list.
- It won't mine co-prescription statistics. Adverse-event report co-occurrence would look like an interaction list and be nothing of the kind.
- It won't truncate a warning. Boxed warnings and label sections are stored whole; an earlier version cut 58% of them mid-sentence, which is worse than showing nothing.
- It won't replace your judgement or the label. It is a reference aid for licensed clinicians. Verify against current labelling before prescribing.
Free for academia, and a professional tier on the way
Everything you have seen on this page is in the free Academic tier. Nothing is held back for a paid one — the paid one does not exist yet.
Academic Edition
Free — study, teaching & research
The whole application, for students, trainees, researchers and academic staff working under supervision.
Download itProfessional Edition
In development
For clinical practice. We are deciding what it should be, and the most useful thing you can do is tell us.
Join the waitlistFree for study, teaching and research
Free for students, trainees, researchers and academic staff. Download it now and register your academic license afterwards — nothing is gated behind the form.
For use under supervision, in training. Any prescription, administration, or recommendation for real clinical use must be made by a licensed healthcare professional exercising their own judgment.
Already downloaded? Register for academic license here